Drug Discovery News: Silence in healthy cells makes FOXR2 a potential cancer target
Drug Discovery News recently highlighted research coauthored by the University of Cincinnati's Timothy Phoenix, PhD, focused on a gene called FOXR2.
FOXR2 is usually not expressed in most healthy cells, but the research team found it is abnormally expressed in more than 70% of 10,000 different adult and pediatric cancer types the team analyzed
The research team also found that FOXR2 bound to the DNA sequences that normally associate with E26 transformation-specific (ETS) transcription factors (ETS TFs), which control the expression of genes with a variety of cellular functions.
“FOXR2 and ETS TFs can interact on DNA and actually turn genes on and off, which can cause cancer,” said Phoenix, assistant professor in UC’s James L. Winkle College of Pharmacy Division of Pharmaceutical Sciences and a University of Cincinnati Cancer Center researcher.
Moving forward, the team aims to learn more about exactly how FOXR2 functions and the proteins it interacts with, with long-term goals of developing targets for new treatments.
Read the Drug Discovery News story.
Featured photo at top of Phoenix in his lab. Photo/Colleen Kelley/UC Marketing + Brand
Related Stories
UC Named Lead Organization for OSHA Training Consortium
January 13, 2003
UC Continuing Medical Education (CME) has been selected as the lead organization for the Occupational Safety and Health Administration (OSHA) Great Lakes Training Consortium by the U.S. Department of Labor.
Ignorance of Stroke s Warning Signs a Barrier to Treatment; More Education Needed, UC Researchers Report in JAMA
January 14, 2003
Demographic groups facing the greatest risk of death and disability from stroke are the least likely to recognize stroke s warning signs and risk factors, according to a study by UC researchers published in the January 15 issue of the Journal of the American Medical Association (JAMA).
UC Researchers Find New Link Between the Eye and the Clock in the Brain
January 21, 2003
Results of a study done by a team of researchers working in the laboratories of Michael Lehman, PhD, professor, Department of Cell Biology, Neurobiology, and Anatomy at the UC College of Medicine, will appear in the February issue of Nature Neuroscience.
Leader of Fetal Surgery to Deliver Lectures at UC
January 31, 2003
An internationally recognized authority on fetal surgery will lecture at the UC Medical Center, representing the first of a series of lectures on fetal surgery presented by the department of Obstetrics and Gynecology (Ob/Gyn).
UC Celebrates National Heart Failure Awareness Week
January 31, 2003
UC Medical Center physicians Lynne Wagoner, MD, and Harvey Hahn, MD, are teaming up with The University Hospital to celebrate National Heart Failure Awareness Week, Feb. 10-14, 2003.
UC College of Nursing Announces New Scholarship for Graduate Program
January 31, 2003
The UC College of Nursing announces the availability of a new scholarship for a full-time student in the Women s Health Graduate Nursing Program.
Inaugural Paul B. Hammond Award Goes To NIEHS Director
February 7, 2003
In a ceremony held Jan. 14, 2003, Kenneth Olden, PhD, director of the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP), received the inaugural Paul B. Hammond award.
UC Stroke Researcher Receives Award from American Stroke Association
February 13, 2003
Joseph Broderick, MD, chair of the University of Cincinnati (UC) Department of Neurology, received the 2003 William M. Feinberg Award for Excellence in Clinical Stroke from the Stroke Council of the American Stroke Association.
NetWellness Experts Answer 20,000th Question
February 18, 2003
Mitchell Rashkin, MD, professor of internal medicine, pulmonary division, at theUniversity of Cincinnati (UC) recently answered the 20,000th question for NetWellness.
UC Partners with Universities in Ohio and Kentucky to Promote Economic Development
February 18, 2003
Four major research universities in Ohio and Kentucky are collaborating to promote economic development in life sciences and biotechnology.