The heart of the matter
'Medical man' and proud Bearcat Dean Kereiakes is one of the world’s premier cardiologists
A proud Bearcat-for-Life and brand new Taft Medalist, Dr. Kereiakes sings the “Alma Mater” with UC Chief Alumni Officer Jennifer Heisey. Photo/UC Alumni Association.
Dean Kereiakes was a bit anxious, which is news along the lines of “Man Bites Dog” for someone who has occasionally believed in his own invincibility. But a confluence of ironic circumstances had placed profound challenges in his path, and he was experiencing a mortal’s vulnerability.
At the end of January, he had humbly received a phone call from Jennifer Heisey, the University of Cincinnati’s chief alumni officer, sharing news of Dr. Kereiakes’ selection as the 2024 recipient of the William Howard Taft Medal for Notable Achievement, the UC Alumni Association’s highest honor. While accustomed to receiving significant tributes recognizing his immense contributions to his field, Kereiakes was especially moved by this gesture from his alma mater. “UC is in my DNA,” he has gladly admitted.
Five days after Heisey’s call, Kereiakes suffered a breakdown of his cervical spine, rendering him “a functional quadriplegic,” in his words, until specialists could address the damage. The situation befell him in the manner that so many catastrophes occur — gradually, then suddenly. A leading scientist, researcher, innovator, author and administrator, Kereiakes is one of the world’s premier interventional cardiologists — and one who proudly remains hands-on. Even as his reputation grew and responsibilities broadened throughout his career, he had continued to tirelessly perform procedures on patients in the cardiac catheterization lab. By his reckoning, he’d done more than 30,000 such procedures in the previous four decades, each time donning the required lead apron that protects the surgeon against the radiation used in the cath lab. But on Feb. 5, 2024, the top of his spine said, “No more,” and succumbed.
The tribute from UC wasn’t the only such award on Kereiakes’ short-term calendar. Hospitalized for a month following urgent cervical spine decompression surgery and given a rigorous rehabilitation program, he held out hope that he would somehow be able to accept the Taft Medal in person on April 11. He already was reconciled to accepting remotely a lifetime achievement award from the Scottsdale Interventional Forum, a national cardiology group of his peers, in early March.
For your typical 71-year-old, a pair of prestigious honors for a prodigious body of work might represent a perfect opportunity to pass the torch and begin easing himself away, even if he wasn’t facing enormous physical hardship. But Dean Kereiakes has never been “typical,” thus the principal source of his anxiety: “I’ve got screws and plates in my entire cervical spine, and I’m supposed to be running at least four FDA pivotal trials for new medical devices in the next couple years.” If you’re Dean Kereiakes, there’s always a lot more to be accomplished, no matter what.
As Kereiakes approached the UC Alumni Celebration and the presentation of the Taft Medal by UC President Neville Pinto, his secondary cause for anxiety was figuring out what his acceptance remarks should include. To him, this wasn’t a go-through-the-motions exercise. Yes, there must be the usual thank-you’s to key people in his life and an acknowledgment of the rewarding nature of his work, all done concisely; Kereiakes loves efficiency and brevity. But more than that, if he was going to have the podium in front of a roomful of people on such an auspicious occasion, he felt the need to offer something of value — to “send a message.” And he realized he had this unique opportunity only because of a timely, masterful message he’d received from a fellow Cincinnatian some 40 years earlier.
Like father, like son: UC in his DNA
Through decades of dedication and innovation, Dr. Dean Kereiakes, A&S ’75, Med ’78, Hon ’14, has become one of the preeminent interventional cardiologists in the world. Photo/Christ Hospital.
In 1998, the late Bill Roberts, M.D., the iconic, 30-year editor of the prestigious American Journal of Cardiology, called Kereiakes “the Denton Cooley of cardiology” when Kereiakes was still just 45. Essentially the “gold standard” in the field in those days, Cooley was the cardiothoracic surgeon best known for performing the first implantation of a totally artificial heart. Twenty-six years later, Cooley’s reputation endures, yet today if you want to pay the supreme compliment to an established but still ascendant cardiologist, you might well call him or her “the Dean Kereiakes of cardiology.” The new “gold standard” is the son of a man whose career had been launched in Fort Knox, Kentucky, as a research scientist for the government involved with early non-orbit space flights in the 1950s.
When he was growing up, Dean Kereiakes was continually exposed to important people and substantial subject matter through the work of his father, an eminently self-made man. Dean’s parents were both first-generation Greek Americans. James G. Kereiakes didn’t speak English when he started school, but he put himself through college on scholarships, earned a pair of advanced degrees from the University of Cincinnati, and became a professor of radiology at UC. Eventually, his son said, Jim Kereiakes was arguably the most prominent radiation physicist in the U.S., receiving every available award in his field. That included the Daniel Drake Medal, the highest honor bestowed by UC’s College of Medicine. It became fairly routine for young Dean to have the opportunity to interact with, and aspire to emulate, such colleagues of his father as Charles Barrett, M.D., the UC radiologist who introduced radiation therapy to the treatment of cancer patients in Cincinnati. Remarkably, Barrett was also president, then chairman and CEO of Western & Southern Life Insurance Co. (now Western & Southern Financial Group).
A physician-scientist the caliber of Dr. Kereiakes comes along once in a generation. He belongs on the Mount Rushmore of interventional cardiology.
David Rizik, M.D. Chief Scientific Officer, Director of Coronary and Structural Intervention, HonorHealth Medical Center
“Charlie Barrett had interpersonal skills uncommon with many physicians, which allowed him to be CEO of Western & Southern in addition to being the head of radiation oncology and establishing the Barrett Cancer Center at UC,” recalled Kereiakes. “The admiration that my parents had for him and his wife was such that, as a kid, I said, ‘I want to be like that.’”
Dean attended UC and seized various opportunities to be a student leader. He joined Sigma Alpha Epsilon fraternity, becoming chapter president as a sophomore, and he was tapped to join the Sigma Sigma men’s honorary fraternity. Each organization provided connections that have proved fulfilling for a half century and counting. Each provided avenues to become a more well-rounded person and leader, which helped create a “bedside manner” that has resonated with all kinds of people throughout a career journey in which he’s much more than a practitioner.
“My affiliations as an undergrad were crucial for learning how to lead others, expanding my network and building interpersonal relationships, all of which is necessary in doing the things I’ve tried to do,” Kereiakes said. “Honestly, I see some other physicians and think they couldn’t make it outside of medicine — they couldn’t sell anybody anything. They may lack personality or don’t seem to be very thoughtful or compassionate. They aren’t imagining themselves as the patient and what it must be like from that perspective. I try to do that each time.”
Kereiakes’ undergraduate experience overlapped with his post-graduate one: His fourth and final year in the College of Arts and Sciences, where he was fast-tracking a degree in biology, was also his first year in med school — a rare accommodation for a university to make to a student. Once there, he further upped his game, becoming valedictorian of the College of Medicine’s Class of 1978. He interned and did his first year of residency at the University of California San Francisco, followed by further residency at Massachusetts General Hospital, then a return to UCSF as a cardiology fellow. As his experience and stature grew during those formative years, he increasingly realized how fortunate he was to be a Bearcat.
The University of Cincinnati is blessed to have such a great graduate who has impacted our community, but also the world, in such a broad way … It is an honor to be part of the same team with him.
John C. Byrd, M.D., Gordon and Helen Hughes Taylor Endowed Chair & Professor, Department of Internal Medicine, UC College of Medicine
“I was extremely well prepared to succeed, coming from UC and the College of Medicine,” he said. “UCSF and Mass General were widely seen as the top two medical programs in the U.S. at that time, and I was more than competitive; I was chief resident at UCSF. I’m grateful and proud to be a UC alumnus.”
Kereiakes’ abilities were such that, when his formal training was completed at UCSF, he was in demand nationally. He and his wife, Anne, whom he’d met when she was a nurse at UCSF, were finalizing their next steps when Dean received a call from Carl Lindner, Jr., who Dean knew as a civic-minded financier back in Cincinnati and the father of one of Dean’s closest high school friends. Kereiakes has had a lot of meetings over the years; Lindner wanted to have what would become the most pivotal in Kereiakes’ life.
“Carl visited Anne and me in our humble apartment in California,” Kereiakes remembered of that January 1984 encounter. “This was in the early days of coronary angioplasty and intervention. We talked about my work and what I was preparing to do next. He said, ‘Dean, what kind of equipment do you need?’ Now, I was working in probably the best cath lab in America at the time, and I told him what we had. He didn’t write anything down, and after that we talked about some other things, and he left.
One of Dr. Kereiakes’ proudest moments was the May 1, 1996, dedication of The Carl & Edyth Lindner Center for Clinical Cardiovascular Research at The Christ Hospital. Here, Dr. Kereiakes is joined by Jack Cook (center), then CEO of The Christ Hospital; and Carl Lindner, Jr. (right), whose vision and generosity were central to Dr. Kereiakes returning to Cincinnati to establish his career. Photo/Christ Hospital.
“Within two months, I got a call from Jack Cook, who was CEO of The Christ Hospital in Cincinnati. Jack told me that Mr. Lindner had donated the exact lab I’d described — all the necessary equipment and capabilities. I looked at Anne and said, ‘Looks like we’re going back to Cincinnati.’”
The gesture reflected Lindner’s legendary love for his community, as well as his penchant for letting his actions speak more loudly than any words could. That dedication found a kindred spirit in the young Dr. Kereiakes, who was similarly passionate about his hometown.
“Mr. Lindner didn’t twist my arm. He didn’t say, ‘If you agree to come to Cincinnati, I’ll do this.’ Instead, he sent a message. He hadn’t put any conditions on it. And if I didn’t get the message, I wasn’t his guy, but he had still done something wonderful for The Christ Hospital and the community. I have since used that same tactic in other key situations to figure out who’s really in the game.”
True to his nature, Carl Lindner was looking out for his city. He didn’t accept the notion that his fellow Cincinnatians had to go to Cleveland or Houston or anywhere else to receive the best cardiovascular care. Needless to say, Dean Kereiakes did get the message, and he would keep his promise to Lindner: Local heart patients and their families would have all they needed just minutes from their doorsteps.
‘It is what we do, and it is who we are’
The University of Cincinnati’s modern North Star is a strategic direction known as Next Lives Here. It refers to accentuating, accelerating and leveraging the culture of innovation that has always been a differentiator throughout the institution’s 205-year history. In presenting the 2024 William Howard Taft Medal, UC President Neville Pinto said that Dean Kereiakes is, in many ways, “Next Lives Here personified.” Pinto cited the work that grew out of Kereiakes’ pledge to Carl Lindner:
- He became the founder and CEO of the largest cardiology subspecialty group in Ohio, which became the cardiovascular service line of The Christ Hospital. This highlighted Kereiakes’ leadership and interpersonal skills in helping fellow cardiologists around Greater Cincinnati change how they’d done business for decades — pooling resources and creating a superior delivery system while enhancing the individual and collective excellence they offered the community.
- He was the founder and Medical Director of The Carl & Edyth Lindner Center for Research and Education, which is one of the nation’s top clinical research sites.
- He directed the establishment of the Lindner Heart Failure Treatment Center, a 30-bed in-patient unit dedicated to the treatment of congestive heart failure.
- He has participated in more than 1,600 clinical research protocols and has authored over 1,200 peer-reviewed scientific journal articles, abstracts and book chapters.
- His research and innovation have brought new technologies, new medical devices and new approaches to his field, generating incalculable ripple effects on countless lives worldwide.
- He has been named one of the Best Doctors in America and received the Samuel Kaplan Visionary Award from the American Heart Association for his cardiovascular research.
“Many of his patients had been told elsewhere that nothing more could be done for them, or they needed procedures that other doctors couldn’t or wouldn’t do,” Pinto said. “Dean’s personal and professional ethos has been to say yes — to try to find a way. And he usually does. When the Food and Drug Administration approves a new medical device or drug to establish the next advance in treating heart patients, there’s a good chance Dr. Kereiakes’ fingerprints are on it.
“Importantly, in doing so much to advance his field, he’s always been adamant about keeping an uncompromising schedule of hands-on work,” Pinto continued. “He also remains especially committed to engaging with his patients in such a way as to never lose sight of the impact of his work in the most human terms.”
In 46 years, I’ve never heard him tell someone he can’t help them. He finds a way … He is dedication personified.
Anne S. Kereiakes, Dean’s wife of 43 years
Pinto’s reference to Kereiakes’ commitment comes with poignancy, as we now know. It was his unyielding dedication to being a fixture in the cath lab throughout those 30,000 procedures that ultimately caused his cervical spine to collapse. But he knows there’s a straight line between that work and the continued development of novel technologies and devices that will save and alter the lives of patients everywhere. He cannot abide the idea that such work is forever behind him, so his recovery has been driven by the intense desire to return to where he belongs. Not returning to the cath lab is not an option — literally.
Not long after his difficult recuperation had begun, he reassured a high-level colleague with a simple declaration that also essentially defines Dean Kereiakes. “I’m going to be back,” he said. “We are medical men. It is what we do, and it is who we are.”
Dr. Kereiakes’ amazing track record for innovations in medical devices, drugs and treatment is a direct result of spending so much time doing procedures in the catheterization lab — over 30,000 and counting. Photo/Christ Hospital.
His return — including adding to the 30,000 cath lab procedures — would have to come with the help of more innovation in an ever-evolving field.
“The way I’ll do it is with a lead-free environment — doing cases in my scrubs without having to wear a lead apron,” he said during his immediate recovery, expecting that particular practical advancement to be realized later in the year.
And he’ll keep learning during that work, and writing about what he’s learned, and thinking “What if…?” while pondering new possibilities that might help coronary patients — his own as well as millions he’ll never see. He has those imminent FDA trials to run, and likely more to follow. That’s where the innovative rubber really meets the road: What ideas will stand up to the exhaustive testing necessary to put new devices, drugs and procedures into play? It’s for the cardiology field of course, but also for the people of Cincinnati — staying true to his word to Carl Lindner 40 years ago.
“We have more novel cardiovascular technologies than the Cleveland Clinic or the Mayo Clinic,” Kereiakes said. “We’re doing over 190 active clinical trials. If you have a stent, there’s a high likelihood that I ran the clinical trial and represented that device to the FDA. What drove me was to make these technologies available to our community.
“Through clinical research trials conducted by the Carl and Edyth Lindner Center for Research and Education, we have tried to bring every new cardiovascular medical device or medication to Cincinnati years before they become commercially available. These have included some 19 first-in-the-world and 41 first-in-the-U.S. novel therapies, medical devices or medications. We have helped countless members of our community, and patients from dozens of different states and from around the world. This work has culminated in thousands of scientific medical publications and presentations, and has contributed to U.S. FDA approval of dozens of new drugs and medical devices.”
Dean Kereiakes says all of this not with any bravado, but rather matter-of-factly. He’s proud that he has kept his word, and he relishes being “the man in the arena,” medically speaking.
‘Time for pause and reflection’
A number of professional admirers showed their fond appreciation for Dr. Kereiakes at the UC Alumni Celebration where he received his university’s top alumni honor.
Once he could see that his recuperation was going well and that he would indeed accept the William Howard Taft Medal in person, Kereiakes had that second source of anxiety to work out. Beyond the obligatories, what message should he send? He pondered the question, then had an epiphany as he realized the juxtaposition he was experiencing. Suddenly, the tables had turned, a striking role reversal had occurred. For decades he’d been the one standing beside a stricken and dependent patient whose hopes and dreams were threatened. Now he was that patient facing uncertainty. What perspectives must he now embrace?
“The event provided time for pause and reflection,” said Kereiakes in a stroke of understatement.
Physician, heal thyself.
On April 11, Dean Kereiakes made his way to the stage, slowly but surely, and gratefully accepted his university’s high honor. Then he offered some brief remarks, expressing gratitude to those with a hand in his success, and pride in being an alumnus of the University of Cincinnati. He spoke, fittingly from the heart, about what he’d come to understand about his current challenges, and how each of us inevitably comes upon a life-threatening or life-defining time that elicits a bit of “Why did this happen to me?”
“Let me propose an alternative approach with the concept that life doesn’t happen to us, but rather for us,” he said. “Only by embracing, rather than lamenting, these life challenges can we focus on that which we can control and ignore that which we can’t.”
While Dr. Kereiakes’ career has necessarily required long hours and constant engagement with his work, his beloved wife, Anne, has always been the rock by his side, as shown here. Together they raised a family with sons David, Andrew and Nick, and daughter Jenna, which now includes seven grandchildren. Photo/UC Alumni Association.
He then referenced the Latin phrase “amor fati,” which translates to “love of fate.” He admitted that “love” might seem like too strong a word when applied to functional quadriplegia, or the need for a heart transplant as in the recent case of Todd DeGarmo, DAAP ’82, Kereiakes’ friend and immediate predecessor as the William Howard Taft Medalist, who was in the audience. Instead, perhaps resolute acceptance is required to see such challenges as opportunities to be a better person, to be more kind, to grow, to help others.
“Although we can’t change the challenges that life unexpectedly presents, we can change our response to them, and this simple revelation gives us control,” Kereiakes said. “Indeed, our response will determine whether the life event defines or defeats us, whether it dictates our future course or whether we subsequently emerge with a new sense of purpose and direction.
“The Roman emperor and philosopher Marcus Aurelius once said: ‘When you arise in the morning, think of what a privilege it is to be alive, to breathe, to think, to enjoy, to love. You have power over your mind — not outside events. Realize this, and you will find strength.’”
As of July, five months after his cervical spinal surgery, Dean Kereiakes is continuing a miraculous recovery, with twice-weekly physical therapy sessions likely continuing through 2024. He resumed seeing patients on a graduated basis in May, and through the development of new innovations to create lead-free radiation protection (something that will be a salvation for the entire community of interventional cardiologists), he expects to return to performing cardiac cath lab procedures in August.
As always, there is much more to be done by this renowned medical man. Patients need him, his profession needs him, and he plans to be there for them. He knows no other way.
Accolades from his peers
A great many outstanding members of the cardiology field weighed in about Dr. Dean Kereiakes during a tribute to him at the Scottsdale Interventional Forum in March 2024. Here’s a sampling:
“Always brings his ‘A’ game, or his ‘A+’ game, to everything he does, whether it’s in the cath lab or in research.”
— Mark Reisman, M.D.
Assistant Professor of Medicine, Director of Structural Heart Disease
Weill Cornell Medicine
New York City, New York
“He has such an enormous impact on the interventional cardiology community. A thinker, an innovator, a leader, a role model, a mentor, a friend.”
— Michael A. Kutcher, M.D.
Emeritus Professor of Internal Medicine, Section of Cardiovascular Medicine
Wake Forest University School of Medicine
Winston-Salem, North Carolina
“A teacher without peer … Always a most gracious gentleman who treats everyone with kindness and respect.”
— James Goldstein, M.D.
Professor of Medicine; Director, Research and Education
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan
“He is the consummate professional. Every time I hear him speak or I interact with him, I always learn something very important and insightful.”
— John Lasala, M.D., PhD
Professor of Medicine, Director, Structural Heart Disease
Washington University School of Medicine
St. Louis, Missouri
“A physician-scientist the caliber of Dr. Kereiakes comes along once in a generation. He belongs on the Mount Rushmore of interventional cardiology.”
— David Rizik, M.D.
Chief Scientific Officer, Director of Coronary and Structural Intervention
HonorHealth Medical Center
Scottsdale, Arizona
The thing about Dean Kereiakes is…
The medical field in general, and the specialty field of cardiology in particular, is blessed with a lot of tremendous practitioners — experts in this most crucial profession. Dean Kereiakes is certainly that, but, according to those who know him, there is something about the man that makes him unique in all sorts of ways, depending on one's perspective and relationship with him.
“Dean Kereiakes is a brilliant, determined, kind individual who has created a world-renowned cardiovascular institute, and has been an original investigator for most of the interventional technologies introduced in the last two decades. What is most impressive about Dean is the loving care he provides to each of his patients. When I have been with him in any public place, thankful patients are constantly approaching him to thank him for his great care. Dean is truly an extraordinary person and a gift to our community.”
— S. Craig Lindner
Co-President, Co-Chief Executive Officer and Director
American Financial Group
“When one looks at the path of most academic cardiologists who have really made an impact, their careers start with the exceptional training pedigree at phenomenal institutions (including the University of Cincinnati) that Dr. Kereiakes traversed. However, Dr. Kereiakes’s path diverged at that point to enter a non-University affiliated academic institution at Christ Hospital where he truly built a research dynasty both in his own career and also for those he trained. With approximately 665 peer-reviewed publications and an h-index of 130, his academic impact falls in the top 0.1% of practitioners. Yet most notable is our first get-together: As a newcomer to Cincinnati, having coffee with him on a weekday morning in Hyde Park, it was amazing to observe the number of his active patients coming up to our table and saying thank you for their empathetic, exceptional cardiovascular care he had provided. Just last week in my clinic, another executive patient with newly diagnosed leukemia sang Dr. Kereiakes’ praises for saving his life as well as providing direction to reduce the stress of his life as a CEO by retiring to enjoy the fruits of his work. The University of Cincinnati is blessed to have such a great graduate who has impacted our community, but also the world, in such a broad way. I’m excited that Dr. Kereiakes has recently joined my department at the University of Cincinnati as an adjuvant professor, extending his work to mentoring cardiology fellows and junior faculty in our Cardiology Division. It is an honor to be part of the same team with him.”
— John C. Byrd, M.D.
Gordon and Helen Hughes Taylor Endowed Chair & Professor
Department of Internal Medicine
University of Cincinnati College of Medicine
“Dean is an intense and compassionate scholar and practitioner of the art of medicine. I first met him as we arrived for our internships at UC San Francisco. It was a high-powered group of super-achievers, but Dean stood out as intensely knowledgeable and curious about medicine — always wanting to learn more. His soft-spoken voice belies his authoritative knowledge and persistent pursuit of the best for the individual patient. Throughout his career, Dean has maintained this treasured combination of practicing medicine at the cutting edge and advancing knowledge through research. He has helped many individual patients navigate serious illness and thousands of developing cardiologists become better doctors. Through it all, his effectiveness has been supported by his wife, Anne, who was an expert clinician in her own right and provided a combination of qualities that no doubt enabled Dean to accomplish even more.”
— Robert M. Califf, M.D.
Commissioner
U.S. Food and Drug Administration
“Dean had the vision to change cardiac care in Cincinnati by promoting sub-specialization in Ohio Heart [the state’s largest cardiology subspecialty group, founded by Abbottsmith and Kereiakes]. He always said, ‘Practice makes perfect.’ Intervention was done by a few, others had to give it up. His leadership in the Lindner Research Center produced multiple local, regional and national firsts.”
— Charles W. Abbottsmith, M.D.
Co-Founder, The Carl & Edyth Lindner Center for Research and Education
The Christ Hospital
“I have admired Dean Kereiakes for more than 35 years during my tenure in the healthcare industry. He has had a profound impact on the face of modern cardiovascular medicine both nationally and internationally. His passion for the profession, his community and the global betterment of the human condition is a testament to his will and belief that no patient should ever be told, ‘We have nothing else to offer you.’ Throughout his career, his incredible genius, his willingness to push the boundaries of scientific inquiry, and his internal drive for excellence — not only for himself but for all those on his team — have made it possible for our community to benefit from many ‘first in its kind’ treatments, many which have revolutionized the way we care for patients with heart disease. All of us in Greater Cincinnati owe a deep debt of gratitude to Dean for his many accomplishments, which he aspired to achieve on behalf of the patients that he so deeply cares about in our community and around the world.”
— Deborah Hayes
President and Chief Executive Officer
The Christ Hospital
“I met Dean at 25 years old working beside him as a nurse in the UCSF intensive care unit. Even then he had an unmatched intensity, pinpoint focus and big goals — but they never seemed idealistic. To know Dean is to believe in him. I’ve watched him apply his motto ‘Always bring your A game’ to his unique compassion for humankind. He somehow functions as if he has more than 24 hours in a day. In 46 years, I’ve never heard him tell someone he can’t help them. He finds a way. I see it as a superhuman quality to spend a lifetime with unfaltering support for me, his kids and grandchildren, while still helping anyone who calls on him. Watching him endure his own health challenges these past few months has only emphasized these qualities. After a grueling surgery on his spine, you would expect anyone to wallow in the experience, but not Dean. He was honoring speaking engagements and assisting people from his hospital bed, meeting his goal of returning to the office to see patients within three months. He is dedication personified.”
— Anne S. Kereiakes
Dean’s wife of 43 years
Featured image at top: Dean Kereiakes receiving the William Howard Taft Medal from UC President Neville Pinto in April 2024. Photo/UC Alumni Association.
Keith Stichtenoth
Special Assistant, Executive Communications
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